Before she became Vice President, Kamala Harris was the first South Asian-American woman elected to the Senate
Tammy Baldwin (D-WI) became the first openly LGBT senator in 2012.
President Reagan's nominee for Associate Justice of the Supreme Court, Robert Bork, found his nomination defeated in the Senate. His name subsequently became a verb, meaning 'to attack or defeat a nominee unfairly through an organized campaign of harsh public criticism or vilification'.
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The Senate failed, barely, to secure a two-thirds majority in favor of convicting President Andrew Johnson
